Two full days of stellar voices at this year’s PopTech can leave the head ailing from overload. The pop-folk band Hem closed was the right remedy. It was an absolute delight to have them close out the day and usher us aspiring thinkers into Maine’s evening air.
You will not believe how the pediatric neuro-oncologist uses the venom from a scorpion’s sting to paint the malignant tumors in children’s brains and lymphatic systems. And, in the process, tap the human spirit.
"Inside the brain it is very difficult to tell the difference between normal brain and cancer. It’s all about millimeters. You’re a millimeter off, take a few grams of tissue that belong safely in the brain, then the patients wake up not as perfect as when they went into the surgery."
To solve this problem, Dr. Olson looked to the natural world. He found his answer in an unlikely candidate: the Israeli Deathstalker scorpion. which has the most powerful venom of any scorpion. The Deathstalker’s venom contains chlorotoxin, a peptide that attaches to certain brain cancer cells while leaving surrounding healthy cells untouched.
Pair this targeting peptide with a fluorescent dye (a beacon) and Dr. Olson came up with“tumor paint.” This method of lighting up cancer cells is 100,000 times more sensitive than an MRI in detecting cancer cells. And, more importantly, the tumor paint shows surgeons precisely what to cut out while leaving healthy cells in place.